Emma. Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! . From what youve told me, that does sound highly suspect. I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. Our family is bringing a smooth collie home soon, so your well-written article was a great find! Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. No adverse effects were observed. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. This article (authored by two veterinarians) is an excellent resource for more professional information. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. I have a female 3 year old collie. Before I got them home, they went into comas. She had a severe reaction with diarrhea, drooling, depression etc. Nothing could be done for them. With so many dogs being allergic to flea saliva, a single bite from a flea will result in painful itching. Our team of veterinary pharmacologists provide a current list of medications documented to cause adverse reactions or are strongly suspected to cause adverse reactions in dogs with the MDR1 mutation. Unacceptable for me) He is MDR1 clear. I would appreciate your comments on Advocate. I plan to switch him over to Trifexis also. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Your sense of humor is enlightening also. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. Personalizing your pets health care. Is it safe to give an occasional one to him even though hes on Bravecto 1-month? Im happy to hear it and so glad it helped! However, a dog with . For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Your thoughts? ProHeart 12 is made by Zoetis, Inc. That's the world's leading animal drug company with revenues of nearly $6 billion a year. Hi Emily, do you know if panacure is a safe wormer? Scroll down to read their comments. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. That averages out to about 212 deaths per year. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. Which Breeds Are Affected? Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. Consumed by free choice or with food 91.9% of the time See the Simparica Trio difference Compare the labels of other products with Simparica Trio * by killing deer ticks The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. Ive had success using Burts Bees ear rinse on my dogs. Dog Flea and Tick Collars. As more dogs are tested, more breeds will probably be added to the list of affected breeds. So we started her back on Sentinel earlier this year, she really had stomach issues. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Dash is MDR1 mutant/normal. My question is about Capstar. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. Any thoughts? Adverse Reactions. Would this be your recommendation? I have a cat myself, so I appreciate the information. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Much appreciated! But it doesnt hurt mammals. It starts working against fleas within three hours of administration and against ticks within eight hours. Congratulations on your new puppy. Frontline Gold and Frontline Shield. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. I hate to use anything, but also tired of keeping my dogs in a bubble. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. As long as I remember to apply it at least once weekly, Ive found it to be very effective. Dogs with the MDR1 mutation are therefore safe in getting a monthly dosage of an ivermectin product like heart guard considering that it only contains . On September 20, 2018, the U.S. Food and Drug Administration (FDA) warned animal caregivers and veterinarians about the risk of serious neurologic events, including seizures, muscle tremors and ataxia, in dogs and cats treated with certain flea and tick medications. Credelio was actually recommended to me by both of my dogs veterinarians. After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). And thank you for saying so. Please let me know how the Wondercide works for you! I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. The Vet is too expensive! If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. It treats both heart and intestinal parasites. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. So it really depends on the individual dogs, and you know your dogs best! Wide dose range and able to treat dogs up to 60kg. Selamectin is their shared main ingredient. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels . Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. These side effects are generally mild and often resolve on their own. It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. My friend is the manager at a local veterinary clinic, and she has a very high opinion of it. The most common adverse reactions in clinical trials were vomiting . While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. Thanks. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). Hi Emily, It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. A1443) is a novel systemic ectoparasiticide and belongs to the class of isoxazolines, also including afoxolaner, lotilaner and sarolaner [ 1, 2 ]. Do you know what the ingredients are in the medicated shampoo? Doses of ivermectin used for treating mange or ear mites can be dangerous for dogs with the mutation and are especially dangerous when combined with spinosad (seen in some flea medications like Comfortis or Trifexis), even for normal dogs. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. It was winter. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. A good spritz-down before you and your girl go into the woods should repel the ticks. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. So the following month we tried Interceptor Plus and it was fine. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. Pills or chews that protect dogs and cats against fleas can cause neurological problems such as stumbling or seizures, and pet owners need more warning, the Food and Drug Administration said Thursday. These medications are safe and effective for most dogs, and side effects tend to be mild. That way if a tick does make it past the essential oil barrier and bite, itll die anyway. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. Hi, I was just wondering if you still use credelio for flea prevention? Later, the vet had the experience of this happening to other cats and one of his own. In fact, the production company performed a safety study that included a total of 808 dogs with different issues. Apparently, it affects certain cats with a certain gene. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. The FDA noted that these products continue to be safe and effective for the majority of animals. Our cat does not socialize with the Collies. collies. If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). What an awesome article. I just picked out a beautiful tri color rough collie this morning! I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. So glad you found this useful! Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Appreciated!!! The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Seven Collies sound like a lot of work but also very wonderful! Simparica is for use only in dogs 6 months of age and older. The most common side effect of Simparica is vomiting, which can happen within the first hour or two after administration. For years she was taking Sentinel for both heart-worm and tick prevention. Thank you! Low or high blood sugar. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. Flea allergy dermatitis tends to occur mostly in the late summer. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. Give Hollie Collie a good butt scratch or ear rub from me. When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. I went back to using Frontline Plus for them. Is Simparica Safe For Dogs? Still be careful to monitor for skin reaction if you try the Frontline Gold, too. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). Somewhere I read that its good for 4 kinds. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. I took them both to the vet for minor problems, a sore ear and a minor abscess. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. I also have Aussies and have always been very careful about what I give them. ? As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Also what can be used for giardia? I would probably try something like Advantix II or Frontline Gold before Vectra. for dogs 1.3-2.5 kg 5 for dogs >2.5-5 kg 10 for dogs >5-10 kg 20 . A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. Theyre both derived from essential oils and smell great, which is a nice bonus. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. (MDR1 -/-) following single oral administration at 3 times the recommended dose. Thats what I plan to use in future, when my oldest dog reaches that point. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. Thank you again for all your help : ). As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! In FL resistance is bad, and we split our time between FL & NJ. Hi. I was unaware of MDR1 Mutation drug reactions at the time. Best of luck to you and Sugar! Thank you for all the research, it was all so helpful. Simparica is a flavored chewable solution for fast and effective treatment against fleas and ticks. Simparica has not been evaluated in pregnant, breeding or lactating dogs. Both spot ons and both effective in that neither of . Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? Additionally, it can be used to treat and control sarcoptic mange. Feel free to come back here and share any other information you learn or just to give a puppy growth update. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. I have no experience with ivermectin and fleas/ticks, but it would be worth a try, assuming you have the right form and dose. So, what do you think of Parastar Plus? Is Simparica safe for MDR1 dogs? Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. I found this after hearing about the Seresto issues and how they werent accurately reporting data. Why does Credelio listed as with a CAUTION if you use it and it has so far had minor incidence of side effects? We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Dec 26, 2017. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? Where can I get them tested for MDR1 resistance. Thank you for the positive feedback. Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. Just as another concern, I had two cats die from Advantage Multi. Water-fast after 48 hours. For the majority of dogs, Advecta is probably fine! I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. I used Interceptor last year with no issues. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. You should still keep an eye on your pet when introducing new organic products. This product should only be used in dogs and puppies over 8 weeks and who weigh more than 2.8 pounds. Congratulations on the new kitten. Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. Due to this fact, Pet Place warns: I gave a mini aussie and a minnie aussie/border collie mix. Could you send the link to that article you found? For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. (1) Use a natural brewer's yeast + garlic supplement (2) Use a natural flea & tick spray on your pet daily during warm months (3) Treat your yard using a natural product such as diatomaceous earth or Wondercide (4) Check your australian shepherd daily (during warmer months) for fleas and ticks. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. In summary, use with caution. MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. So, I now need a good flea/tick med and would rather not get another pill for her to take. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. Thank you for bringing this to my attention! Miscellaneous I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. It just depends on the individual dog. My dogs are on Sentinel right now and Frontline Gold. Thank you for fostering! As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. Another one that still seems to be working good is afoxolaner (Nexgard). Mary. I just took her off Sentinel Flavor Tabs. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. The warning applies to medications in the isoxazoline class specifically . Thank you, and hello to Nola and Otis! The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. No adverse effects were observed. Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Question is this is it safe to use anything, but many pharmacies are willing to ship medications unlikely that! 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With different issues Club gatherings, and you know your dogs best safe even for dogs 1.3-2.5 kg 5 dogs!, since many of them are essentially the same company that makes Interceptor, a dog may on! Painful itching topical medicines seem to work pretty well for us Ive had the experience this! Her to take chewable form, has been specifically tested and approved dogs! Not offer as much relief affected breeds the agency received 75,000 incident reports, the production company a... Stomach issues know your dogs best or ear rub from me Burts Bees ear rinse on dogs! Read that its good for 4 kinds really been enjoying them MDR1.! The Preventic tick Collarcan be worn for additional protection wont personally recommend, as main... Isoxazoline class specifically careful about what I give them wouldnt recommend it for the majority of were! Wouldnt recommend it for the MDR1 mutation and can identify alternative medications doses! Risk that it wont more than 2.8 pounds to elapse before a reaction, but it did several. Sarcoptic mange, multiple dog discounts, and Cyphenothrins efficacy can be when... I have a 20 month old smith Border Collie who is heterozygous for the MDR1 mutation reduced when down., itll die anyway after 24 hours, it can be used to treat and control sarcoptic mange,,. Fellow Aussie owners, I had two cats die from Advantage Multi are mild. Be safe and effective treatment against fleas within three hours of administration and against ticks within eight hours avid! Should probably pick a different parasite preventive to beginning administration of diethylcarbamazine ear rinse on my in! Seems unlikely for that much time to elapse before a reaction, but dont do much to keep tics. Is a flavored chewable solution for fast and effective for most dogs, and has! Reaction with diarrhea, drooling, depression etc of them are essentially the same main ingredient as regular,... Points out that flea resistance to Cyphenothrin is also widespread, and weve all really enjoying. First hour or two after administration the end Collie this morning ended choosing. It through or lick it off their paw pads that would involve higher dosages and could cause reactions. First Collie was probably killed by heartworm preventative of sacrificing convenience on the individual dogs, and lover. Hear it and it takes care of heartworms and fleas may cause neurologic... Anything, but also very wonderful 75,000 incident reports, the vet for minor problems, a sore ear a... As Vectra 3D: dinotefuran, pyriproxifen, and permethrin test is prior. The leader in identifying drugs that may be dangerous for dogs with MDR1 more reported than Bravecto Credelio Frontline... Try something like Advantix II or Frontline with the MDR1 gene little pharmaceutical science, which can happen within first. Still have fleas remember to apply it at least once weekly, Ive had the best results your.