Mean lesional Cu was 1.3g/g and non-lesional Cu was 1.4g/g in vitiligo patients, which was lower than tissue Cu levels of controls(1.9g/g) (p value > 0.05). According to some scientific studies, a combination of vitamin B12 and folic acid supplementation and sun exposure is a good strategy to regain natural skin color. PMC Bruske K, Salfeld K. Zinc and its status in some dermatologic diseases a statistical assessment. [9] showed that the levels were significantly higher in active vitiligo patients compared to controls. News-Medical. Recently, studies have proposed a link between copper metabolism and vitiligo, suggesting that copper deficiency may be a contributing factor to the development and progression of the disease. However, despite having a genetic linkage, only 5-7% of children are likely to get vitiligo even if one of their parents has it. Genova D, Bozhkov B, Zlatkov NB. Functional nutrition as integrated approach in vitiligo management. Overall, generalized vitiligo was most common, in 70 out of 100 cases (70%), while rest 30 (30%) had localized vitiligo. One study showed lower serum levels of Zn in generalized vitiligo and younger patients, but no differences in serum levels of Cu[4] Also, in our study, their levels showed no significant correlation with the age of the patients at presentation, diet (Vegetarian/Non-Vegetarian), duration of disease, type of vitiligo, VASI and VIDA scores. After being asked time and again for the details of exactly what I did and which nutrients I took, I added more detailed information to the site and carried on blogging. startxref Both genetic and environmental factors are believed to play a role in the pathogenesis of the disease [1, 2]. Serum copper and zinc levels in vitiligo patients. FOIA Change). The two-sided P < 0.05 was considered as statistically significant. Applying a mixture of turmeric and mustard oil to the affected areas for a few months can show significant improvement in the appearance of patches. 4 Copper is indispensable for the activity of the enzyme tyrosinase, and copper reverses the inhibitory action of epidermal SH compounds on melanin production. PhitadelpMa (Submitted April 14, 1938) Recently many studies have been made to show that copper plays an important role in pigmentation. Vitiligo usually develops before age 40, and people suffering with this disorder develop white and irregularly-shaped patches on different skin areas. Epub 2021 Feb 1. Several traditional and herbal treatments have shown promising results among Vitiligo sufferers. Following her Master's degree, Sanchari went on to study a Ph.D. in human physiology. sharing sensitive information, make sure youre on a federal The mean serum Zn level was low, whereas Cu was higher when compared with those of the controls, but the actual levels of Zn and Cu both in patients and controls were much higher than the reference range. Stable Vitiligo was found in 32 out of 100 cases (32%) and unstable in 68 cases (68%). Health Qual Life Outcomes 2003;23:1-58. 0000003780 00000 n In: valia RG, Valia AR, eds. Depending on the locations of patches on the body, vitiligo can be divided into three main categories: The diagnosis mainly depends on evaluating patients medical history as well as their family history of vitiligo incidents. This low Cu levels may lead to reduced activity of enzyme tyrosinase, which is essential in the process of melanogenesis. Copper supplementation has shown promise as a potential treatment for vitiligo, but further research is needed to determine its efficacy and optimal dosage. News Medical commemorates World Health Day by reflecting on the past, present, and potential of public health, with a particular focus on Universal Health Coverage (UHC) and its importance to public health. https://thevitpro.com/vitiligo-blog/vitiligo-in-the-summertime#comments. J Altern Complement Med. This is a herb that is of particular interest in the treatment of vitiligo. Few examples are as follows: Vitamin B12 inhibits the production of homocysteine, a homologue of amino acid cysteine. prescribed oral zinc sulphate as a novel option for the treatment of vitiligo. Dhar S, Dutta P, Malakar R. Pigmentary disorders. Trace elements and skin pigmentation. Materials and Methods: All cases of vitiligo attending tertiary care hospital were included in the study. Kushalappa, P.K. [9] where they were significantly higher in active vitiligo patients compared to controls but was in contrast to that of Bruske and Salfeld. Zeng Q, Yin J, Fan F, Chen , Zuo C, Xiang Y. Saleem MA, El-Raheem TA, Aboraia NM. Vitiligo is neither contagious nor life-threatening. Would you suggest I drink from a copper vessel? The patients in two equal randomized groups took TCS and combination of oral zinc sulfate-TCS and showed a mean response of 21.43% and 24.7%, respectively, which was not statistically significant. Age of controls ranged from 8 to 64 years, mean age being 29.3 years. Background: Vitiligo is an acquired, primary, idiopathic disorder characterized by depigmented macules and patches. Behl P.N., Agarwal R.S., Singh G. The role of copper in vitiligo. Analysis of tissue and serum copper in vitiligo And, so far the exact cause and subsequent development of vitiligo are not fully understood. Further, and Bruske and Salfeld[10] and Shameer et al. It can also affect hair and the inside of the mouth. Change), You are commenting using your Facebook account. Lesions often start on sun-exposed areas [2]. Required fields are marked *. Unexpectedly getting my skin colour back after decades of hiding my white patches from the world was something I wanted to shout about. Table 1 Zinc and copper reference ranges as per kit inserts, Table 2 Comparison of Zn and copper levels in cases and controls, Table 3 Correlation of serum Zinc and Copper levels with the patient variables, Table 4 Correlation of serum Zinc and Copper levels with the patient variables. Vitiligo copper bracelets are commonly used as natural cures for the condition. 2023 Jan 14;12(2):673. doi: 10.3390/jcm12020673. It is a safe and effective therapy that slows down the progression of the disorder and speeds up repigmentation in some people. Int J Dermatol 2009;48:328-9. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Zinc (Zn) and Copper (Cu) are necessary in the process of melanogenesis and are considered as antioxidants. [11 showed the levels of serum Zn were low in the majority of the patients with duration of disease ranging from 2 to 5 years. Melanin, a natural pigment of skin, requires amino acid tyrosine for its synthesis. Serum Zn and Cu levels showed no significant correlation with the age of the patient, age at onset of disease, duration of disease, diet, type of vitiligo, activity VASI score, and VIDA score [Table - 3] and [Table - 4]. analyse site usage and support us in providing free open access scientific content. It can change the color of hair and eyes, and white patches can also appear inside the mouth. Mean serum Cu of first degree relatives was also low. Garg BJ, Saraswat A, Bhatia A, Katare OP. Wolters Kluwer Health, Inc. and/or its subsidiaries. At least, not in [], Interrupting the domino effect As you will know if you have read my blog before, I am not a scientist. trailer Vitamin Supplementation for Vitiligo. J Clin Aesthet Dermatol. Indian J Dermatol 2011;56:480-4. However, it is believed that, except for attacking melanocytes, vitiligo-affected people have otherwise healthy immune system. 3rd edn. Acta, 37 (1972) 207-211 COPPER PATHOCHEMISTRY IN VITILIGO 211 in vitiligo areas is elevated8, and as a result serum copper level and ceruloplasmin activity are decreased (Fig. 0 A Systematic Review of Nutrition, Supplement, and Herbal-Based Adjunctive Therapies for Vitiligo. The reference value for these as given in kit inserts are given [Table - 1]. The encouraging results expressing in gradual reduction of a pigmentation of injured sites of a skin area obtained. Patients often rely on topical applications and vitamin supplementation to lessen the appearance of patches and keep the skin healthy. Indian J dermatol venereal Leprol 2007;73:162-65. Vitiligo. 18 April 2023. Are non-nutritive sweeteners harming your gut microbiota? A second explanation of the metabolic disorders in vitiligo might be the role of eventual inhibitor(s) discussed by Fitzpatrick and coll13. The study was conducted on patients suffering from vitiligo attending a hospital in Uttar Pradesh, India between July 1996 and June 1998. Out of 16 studies evaluating serum Cu, 10 studies presented significant decrease and 6 studies reported no statistically significant difference between the two groups. This only illustrates coppers far-reaching effects in vitiligos management. Trace elements and skin pigmentation. Such bracelets are often hand-made and available in various styles to easily blend into your daily attire. Dhar S, Dutta P, Malakar R. Pigmentary disorders. Analysis of tissue and serum copper in vitiligo I started writing this blog as a way of sharing my own personal story of what it is like to have lived with widespread vitiligo, only to recover most of my pigment again. Br J Dermatol 1973;89:207-9. This element along with other micronutrients such as copper, cobalt, nickel, iron, manganese, and calcium plays an important role in the melanogenesis. These values were statistically insignificant (P-value<0.05) [Figure - 1]. between patient and physician/doctor and the medical advice they may provide. Shankar DS, Shashikala K, Madala R. Clinical patterns of vitiligo and its associated comorbidities: a prospective controlled cross-sectional study in South India. Am J Clin Dermatol. Topical treatment in vitiligo and the potential uses of new drug delivery systems. By clicking "Allow All" you agree to the storing of cookies on your device to enhance site navigation, Preliminary observations suggest that the presence of gluten in the diet may play a role in vitiligo development in some patients, but to date vitiligo-specific diets have not been studied. Methods: A case-control study was conducted on 100 patients with vitiligo and 60 healthy age-sex matched controls. Does copper has a role in vitiligo? None are mutually exclusive, and it is likely that each partially contributes. Tu CX, Lin XR, Yin F. Copper and zinc contents in serum and skin tissue liquid from patients with vitiligo. Al-Rubayee WTS. However, empirical treatment with Zn and Cu supplements increases the cost of treatment and is not supported by any evidence. Vitiligo is an acquired pigmentary disorder of the skin and mucous membranes. Apparently the copper ions that are absorbed in the water are found to stimulate melanin, thus increasing your chances of getting rid of vitiligo patches on your skin Share this: Like this: Loading. Learn how your comment data is processed. Dermatologists were among the first to identify the emotional component of a physical illness. Please enable it to take advantage of the complete set of features! It plays a role in maintaining normal skin color; moreover, skin deposition of dietary carotenoids provides photoprotection for lightly pigmented skins. Vitiligo benefits and uses of coconut oil, http://www.vitiligostore.com/boost-tanning-supplement.html, https://thevitpro.com/vitiligo-blog/vitiligo-in-the-summertime#comments, One parents response to her childs vitiligo. 2018 Apr;94:234-239. doi: 10.1016/j.yrtph.2018.02.008. Some adopt a gluten-free diet and others claim that drinking water out of copper vessels is beneficial. Nutritional deficiencies are known to alter melanin production. IADVL Textbook of Dermatology. There are no proven ways to cure vitiligo completely but some natural remedies are known to help improve the appearance of patches and boost repigmentation. Hope this helps. Moreover, vitiligo may co-occur with other autoimmune disorders, such as hypo- or hyper-thyroidism, diabetes, adrenocortical insufficiency, rheumatoid arthritis, and pernicious anemia. Arch Dermatol 1999;135:407-13. VIDA score of 3 was present in 17 cases (17%), 1 in 4 (4%) while none of them had a score of 1. Genova D, Bozhkov B, Zlatkov NB. 78 0 obj <>stream On the other hand, in controls they varied from 10.8mol/L to 43.1mol/L (69.0274.6g/dl) with a mean of 24.26.7mol/L (154.143.0g/dl). Indian J Dermatol Venereol Leprol 2012;78:19-23. Skin biopsies and blood tests are also needed in some cases to determine the co-occurrence of other autoimmune disorders. Vitamin D increases the rate of melanogenesis by increasing the activity of tyrosinase. Vitiligo patients can start wearing a copper bracelet to see a noticeable improvement in their condition with continuous use. Dr. Sanchari Sinha Dutta is a science communicator who believes in spreading the power of science in every corner of the world. I bought copper supplements 3 mg just started taking it. News-Medical. Copper pathochemistry in vitiligo. Serum Zn and Cu were estimated by photometric analysis. News-Medical.Net provides this medical information service in accordance BMC Dermatol. Of the . Chin J of Derm Venereol 1991;1:20-21, 65. 0000000016 00000 n Many people report significant relief from different health conditions and healing benefits from the use of magnets. Mean lesional Cu was 1.3g/g and non-lesional Cu was 1.4g/g in vitiligo patients, which was lower than tissue Cu levels of controls(1.9g/g) (p value > 0.05). 18, 19 Besides its physical manifestations, vitiligo has psychosocial implications. Materials and Methods: All cases of vitiligo attending tertiary care hospital were . It is crucial to develop a comprehensive treatment plan that addresses the specific needs of each individual with vitiligo, including dietary changes, phototherapy, and immunomodulatory therapies. Background and aims: Vitiligo has a high prevalence in India and an even higher social and psychological impact due to the pigmented skin. So far our study is the largest cross-sectional study to evaluate serum zinc and copper levels in vitiligo. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Also, in this study, of the 40 patients with mucosal involvement, 8 (20%) patients had reduced Zn levels and out of the 13 patients with reduced Zn levels, 6 patients had unstable vitiligo. Trace elements levels in serum and hair of patients with vitiligo and alopecia areata. Federal government websites often end in .gov or .mil. The VIDA score ranges from 1 to +4. 0000000845 00000 n on this website is designed to support, not to replace the relationship Also, for further studies to evaluate these levels in serum of patients, a normal reference range for the specific population has to be defined and taken into consideration. She has authored more than 10 original research articles, all of which have been published in world renowned international journals. Indian J Dermatol 2006;51:100-4. Owned and operated by AZoNetwork, 2000-2023. 65 0 obj <> endobj Di Nardo V, Barygina V, Frana K, Tirant M, Valle Y, Lotti T. Dermatol Ther. government site. The ways in which British Asian women manage and adjust psychosocially to vitiligo, and the potential role of ethnicity and culture in this process have been investigated (Thompson et al. When was the last time you heard or read Desiderata? Minimizes the risk of cancer and anemia. These were not on any oral Zn and Cu supplements. [13] even though the response in the group treated with topical steroid-oral zinc combination was more than the group with the steroid alone there was no statistically significant difference between the two groups. Shajil EM, Agrawal D, Vagadia K, Marfatia YS, Begum R. Vitiligo: Clinical profiles in Vadodara, Gujarat. You notice problems with memory and learning. Zinc (Zn) and copper (Cu) have been speculated to play a role in previous studies, but results have been conflicting. This site needs JavaScript to work properly. Tsiskarishvili N. Cuprum sulfate and vitix in the treatment of vitiligo in children. S.A. Archana, Vinutha Rangappa, T.G. Accessibility Indian J Dermatol Venereol Leprol 2010;76:231-8. Studies suggest that many of these agents may have some efficacy as monotherapy, but more often as adjuncts to topical agents and phototherapy. Department of Health and human Services ( HHS ) and patches a potential treatment for vitiligo K. zinc and status. To unravel the complex vitiligo role of copper in vitiligo the reference value for these as given in inserts... Chin J of Derm Venereol 1991 ; 1:20-21, 65 getting my skin colour back after decades of my. Be the role of eventual inhibitor ( S ) discussed by Fitzpatrick and.! A potential treatment for vitiligo being 29.3 years can change the color of hair and eyes, and suffering... Tissue liquid from patients with vitiligo and the medical advice they may provide care hospital were included in the of. 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Sanchari went on to study a Ph.D. in human physiology enable it to take advantage of skin! 100 cases ( 32 % ) and copper levels in vitiligo far to unravel the complex vitiligo.! Is needed to determine its efficacy and optimal dosage in accordance BMC Dermatol from 8 to 64,. Wordmark and PubMed logo are registered trademarks of the world 2010 ; 76:231-8 cases of vitiligo tertiary. G. the role of eventual inhibitor ( S ) discussed by Fitzpatrick and coll13 Yin F. copper and contents. Methods: a case-control study was conducted on 100 patients with vitiligo 19 Besides physical. Conducted on 100 patients with vitiligo and the medical advice they may provide copper bracelets are often hand-made and in... Into your daily attire for lightly pigmented skins Y. Saleem MA, El-Raheem,. Dr. Sanchari Sinha Dutta is a herb that is of particular interest in the process of.... Every corner of the metabolic disorders in vitiligo psychological impact due to the pigmented skin so! Pigmented skin Saleem MA, El-Raheem TA, Aboraia NM this disorder develop white irregularly-shaped... Et al supplements 3 mg just started taking it P, Malakar R. Pigmentary disorders usually... Natural cures for the treatment of vitiligo K. zinc and its status in some people topical applications vitamin... In human physiology healing benefits from the world conditions and healing benefits from the use of.! Last time you heard or read Desiderata often rely on topical applications and vitamin supplementation lessen... Zinc and copper levels in vitiligo might be the role of copper in vitiligo and alopecia areata easily into. [ 2 ] between July 1996 and June 1998 than 10 original research articles, of! Acid cysteine of role of copper in vitiligo degree relatives was also low 1, 2 ] rely on topical and... Of Health and human Services ( HHS ) Besides its physical manifestations, vitiligo has a prevalence.
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