The same patients also waited longer to visit the doctor than patients from higher-income neighborhoods. You can also access information from the CDC. Our lab strives to see how molecules get together and come to life. Show more detail. Labs. March 15, 2023. February 22, 2023. Our research is focused on elucidating the mechanism of Hsp90 chaperone function and its role in human disease, microtubule nucleation & centrosome structure, and the structure and cell biology of phage-encoded tubulins. Extended Data Fig. Furthermore, the winged-helix domain of LEM2 activates the ESCRT-II/ESCRT-III hybrid protein CHMP7 to form co-oligomeric rings. yifan.cheng@ucsf.edu +1 415 514-9708 We are interested in studying the three-dimensional structures of macromolecular complexes: their structural architectures, the regulation of their function and the dynamic processes of their assembly and disassembly, by molecular electron microscopy (cryoEM). 94143. He obtained a PhD in Clinical Psychology at Palo Alto University, with an emphasis in neuropsychology. Structural basis of membrane deformation by the ESCRT-III family of proteins (107.4). In 2017, Walter and Costa-Mattioli teamed up with Susanna Rosi at UCSF, an expert on traumatic brain injuries. The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy. Speaker. A Frost, R Perera, A Roux, K Spasov, O Destaing, EH Egelman, O Brandman, J Stewart-Ornstein, D Wong, A Larson, CC Williams, GW Li, DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, B Antonny, C Burd, P De Camilli, E Chen, O Daumke, K Faelber, M Ford, S Guerrier, J Coutinho-Budd, T Sassa, A Gresset, NV Jordan, K Chen, M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, C Mim, H Cui, JA Gawronski-Salerno, A Frost, E Lyman, GA Voth, PS Shen, J Park, Y Qin, X Li, K Parsawar, MH Larson, J Cox, Y Cheng, J McCullough, AK Clippinger, N Talledge, ML Skowyra, MG Saunders, R Kalia, RYR Wang, A Yusuf, PV Thomas, DA Agard, JM Shaw, A Frost, I Lax, A Wong, B Lamothe, A Lee, A Frost, J Hawes, J Schlessinger, Annual review of cell and developmental biology 34, 85-109, S Koirala, Q Guo, R Kalia, HT Bui, DM Eckert, A Frost, JM Shaw, Proceedings of the National Academy of Sciences 110 (15), E1342-E1351, Journal of neurochemistry 78 (4), 920-923. UCSF Profiles is UCSF's version of the ground-breaking, open source "Profiles Research Networking Software" that was developed under the supervision of Griffin M Weber, MD, PhD, with support from Grant Number 1 UL1 RR025758-01 to Harvard Catalyst: The Harvard Clinical and Translational Science Center from the National Center for Research Resources and support from Harvard . PMC Our lab focuses on understanding molecular chaperone-driven protein quality control mechanisms that facilitate protein folding and cellular stress responses. Epub 2015 Jun 3. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. It also made possible discoveries in Agards lab about proteins that help other proteins maintain their proper shape, a process that has major implications for cancer and diseases such as Alzheimers disease that are characterized by misshapen proteins. Sulina, 46, was hospitalised and . Accompanying this is an effort to develop new technologies for high-resolution cryoEM and fluorescence light microscopy. Languages spoken: English. 2022 Dec 5;221(12):e202201024. The https:// ensures that you are connecting to the The reformation of sealed nuclei requires ESCRTs (endosomal sorting complexes required for transport) and LEM2, a transmembrane ESCRT adaptor2-4. Do organisms need a brain to learn? 1 |. He is exploring what causes these disparities and how they can be addressed by diving deeper into the data. University of California, San Francisco. Does Taxing Sugary Drinks Lead to Improved Health During Pregnancy? 2022 Oct 4;10:1012768. doi: 10.3389/fcell.2022.1012768. Protein synthesis. 4 |. We are interested in studying the three-dimensional structures of macromolecular complexes: their structural architectures, the regulation of their function and the dynamic processes of their assembly and disassembly, by molecular electron microscopy (cryoEM). Until recently, such a feat would have been considered impossible, but in the past five years, such breakthroughs have become almost commonplace here, part of a resolution revolution being led by UCSF researchers. Her talk on this work recently won the top prize in the 2023 UCSF Grad Slam. Electron-counting cameras really provided a quantum leap in our ability to understand a proteins underlying chemistry both how it functionsand how you could design drugs that bind to it.. . After beginning his professional life working for the North Devon Parks Department, he then relocated to London and began a . Search form. Is there additional information on UCSF websites that would be helpful to you? Livestream Information Zoom February 16, 2021 (Tuesday) 12:00pm Meeting ID: 96151442305. Associate Professor. We study biomolecular machines that are too fragile to purify to homogeneity, too large or too flexible to crystallize, or that depend upon lipids for their form and function. a***@ucsf.edu. This pruning of synapses is normal and necessary to form specialized neural circuits. HHS Vulnerability Disclosure, Help Academic Office Information. Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. sharing sensitive information, make sure youre on a federal Disruption of these events in human cells prevented the recruitment of downstream ESCRTs, compromised spindle disassembly, and led to defects in nuclear integrity and DNA damage. Another leading cryo-EM researcher at UCSF, Adam Frost, MD, PhD, who joined the university as an assistant professor in 2014 to take advantage of the power of this new technology, has been leading efforts to use cryo-EM to determine how new classes of drugs bind to their target proteins at the atomic level. But at UCSF, the culture nurtures us to do things that everybody else thinks are impossible.. Activated CHMP7 forms polymeric rings via its ESCRT-III domain, exposing, Extended Data Fig. The Omicron Effect: Can We Predict the Next Viral Killer. Cell biology: Double agents for mitochondrial division. Homology modeling and crosslinking-mass spectrometry (XL-MS) consistent with a WH, Extended Data Fig. Thanks to their recent advances in cryo-electron microscopy (cryo-EM) a technique whose inventors were honored with the 2017 Nobel Prize in Chemistry these researchers have enabled rapid progress in the search for more precise and powerful therapies for a wide array of human diseases. 2022 Nov 15;132(22):e158897. Membrane trafficking: decoding vesicle identity with contrasting chemistries. In the photo, Adam's daughter could be seen looking stunning in a gown and holding a glass of fizz before heading . eIF2B Conformation and Assembly State Regulate the Integrated Stress Response. Adam Frost (born 21 August 1972) is a British author, best known for his children's books Ralph the Magic Rabbit (shortlisted for the Waterstones Children's Book Prize) and The Epic Book of Epicness (winner of the Blue Peter Book Award).He also designs information graphics for The Guardian, and teaches and writes on the subject. Verified email at ucsf.edu - Homepage. January 12, 2022 - Adam Antebi (Max Planck Institute for Biology of Ageing) Nucleolar regulation of longevity . CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier. Visualizing Membrane Mechanics: From Nuclear Envelope Integrity to Photon Harvesting All Rights Reserved.Department of Molecular Biology, Assistant Professor, Biochemistry and Biophysics, Free and open to the university community and the public, Fred Hughson, Department of Molecular Biology, Genetics and Molecular Biology Training Grant, Genome Editing Shared Resource (Rutgers-CINJ), Glenn Center For Quantitative Aging Research, Lewis-Sigler Institute for Integrative Genomics. Adam Frost's Phone Number and Email Last Update. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Endosis and exosis: new names for fusion and budding. Thomas Laboratory 003. B. in Physics. Nature 522, 236239, doi:10.1038/nature14503 (2015). The 10 finalists were selected by a panel of screening judges who reviewed more than 30 initial video entries. Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof M, Tsai K, Stojkovic V, Noda-Garcia L, Young ID, Myasnikov AG, Kleinman J, Palla A, Floor SN, Frost A, Fraser JS, Tawfik DS, Fujimori DG, Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P, Mary Munson, Dante Lepore, Michael Feyder, Guendalina Rossi, Alexander Czuchra, Leonora Martnez-Nez, Lillian Kenner, Adam Frost, Patrick Brennwald, Michael Schoof, Morgane Boone, Lan Wang, Rosalie Lawrence, Adam Frost, Peter Walter, Sun M, Azumaya C, Tse E, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA, Miller-Vedam LE, Bruning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS, Ming Sun, Caleigh Azumaya, Eric Tse, Daniel Southworth, Kliment Verba, Adam Frost, Yifan Cheng, David Agard, Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK, von Appen A, LaJoie D, Johnson IE, Trnka MJ, Pick SM, Burlingame AL, Ullman KS, Frost A, Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR, Iwasa JH, Vershinin MD, Sundquist WI, Frost A, Mary Munson, Dante Lepore, Michael Feyder, Guendalina Rossi, Alexander B Czuchra, Lillian Kenner, Leonora Martnez-Nez, Adam Frost, Patrick Brennwald, Stojkovic V, Myasnikov AG, Young ID, Frost A, Fraser JS, Fujimori DG, Rossi G, Lepore D, Kenner L, Czuchra AB, Plooster M, Frost A, Munson M, Brennwald P, Mary Munson, Dante Lepore, Michael Feyder, Guendalina Rossi, Alexander B. Czuchra, Lillian Kenner, Leonora Martinez-Nunez, Jacqueline M. Forson, Adam Frost, Patrick Brennwald, Henry C. Nguyen, Nathaniel Talledge, John McCullough, Abhimanyu Sharma, Frank R. Moss, Janet Iwasa, Michael Vershinin, Wesley I. Sundquist, Adam Frost, Romanov V, McCullough J, Gale BK, Frost A, Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A, Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N, Romanov V, Samuel R, Chaharlang M, Jafek AR, Frost A, Gale BK, Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A, Zurita Rendn O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J, Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky J, Frost A, Borner GH, Weissman JS, Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P, Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A, Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS, Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE, Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A, Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S, Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ, Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M, McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A, John McCullough, Leremy Colf, Marissa Saunders, Matthew Lalonde, Gaelle Mercenne, Wesley Sundquist, Adam Frost, Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A, Adam Frost, Wes Sundquist, John McCullough, Marissa Saunders, Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM, Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS, Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS, Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger VM, Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K, Jin WL, Frost A, Polleux F, Adam Frost, Carsten Mim, Rushika Perera, Krasimir Spasov, Edward Egelman, Pietro De Camilli, Vinzenz M Unger, Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM, Cole CD, Frost AS, Thompson N, Cotten M, Cross TA, Busath DD, Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J, Schlessinger J, 2023 The Regents of the University of California, Critical reviews in biochemistry and molecular biology, Annual review of cell and developmental biology, Proceedings of the National Academy of Sciences of the United States of America. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A. Proc Natl Acad Sci U S A. In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. S412C 600 16th. UCSF News. government site. Search. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. What is learning? Contributors : Lan Wang; Morgane Boone; Rosalie E Lawrence; Adam Frost; Peter Walter; Michael Schoof. J Clin Invest. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Structural basis of mitochondrial receptor binding and constriction by DRP1. Facility Access & Rules; Scheduling & iLab; FEI T12 TEM; FEI T20 TEM; Talos Arctica Cryo-TEM; Glacios Cryo-TEM; Aquilos 2 Cryo-FIB; Titan Krios Cryo-TEM; Documents. Extended Data Fig. 12:30 pm . Keck Foundation Advanced Microscopy Laboratory is located at the Misson Bay Campus of the University of California at San Francisco. Application significantly improves Thon ring quality and 3D reconstruction resolution.NOTE: This software may only be downloaded and used for free by academic and/or non-profit users. His big break came when he worked with Geoff Hamilton . My English Home: Monty Don. Ribosome-associated quality control and CAT tailing. 600 16th St., S101. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Nat Rev Mol Cell Biol 18, 229245, doi:10.1038/nrm.2016.153 (2017). He built artificial intelligence models to analyze the data and found that diabetes patients from lower-income neighborhoods were prescribed cheaper, possibly less effective treatments. The habits of Stentor coeruleus, a single-celled organism that lives in ponds, show that a brain is not required for living things to learn and adapt to changing conditions. Interplay of the nuclear envelope with chromatin in physiology and pathology. The strengths of our program at UCSF encompass: Atom-level analyses using physics-based methods and fundamental principles of physical chemistry. UCSF graduate programs were among the first in the country to break down traditional barriers between departments and disciplines, and interdisciplinary thinking permeates the program curriculum and faculty. The recent work with cryo-EM has been so successful that many researchers at UCSF have begun clamoring for a share of the limited microscopy time available on shared scopes. Adam Frost, PhD, MD. Rajan will go on to represent UCSF at the UC system-wide Grad Slam on May 5. Frost and Cheng have also been using cryo-EM to understand how signaling proteins on the surfaces of cells key targets for pharmaceuticals from pain killers to cancer therapies are influenced by the cell membranes in which they float and how proteins can bend and shape the membranes. Homology modeling, Extended Data Fig. The live event final judges were Abby Buchwalter, PhD, assistant professor at the Cardiovascular Research Institute, Dan Lowenstein, MD, the Robert B. and Ellinor Aird Professor of Neurology at UCSF; Florie Mar, PhD, global medical science director for medical affairs at Genentech and founder and president of Youreka Science; Elise Marsan, PhD, a postdoc and first prize winner of Postdoc Slam 2022; and Carla Washington, PhD, Graduate Division Alumni Association president at UCSF. 3 |. 2021-12-06 | Preprint. Im really grateful to have received two awards, and it is a testament to the support I have received at UCSF, Rajan said. Twitter Facebook LEM2-LCD bundles. . eIF2B conformation and assembly state regulates the integrated stress response. Research Interests. To do this, he integrates cryo-EM with genetics, biochemistry, and diverse imaging techniques. Structural basis of membrane invagination by F-BAR domains. frost@biochem.utah.edu (415) 514-4825 UCSF - Professor Adam Frost - Dept. Olivia Teter, a graduate student in the Bioengineering Program at UCSF, won third prize and received $1,000 for her talk on Nipping Neurodevelopmental Disorders in the Bud. She used a metaphor to explain her research, suggesting that immune cells called microglia act like gardeners that prune synapses in the brain. A native of Utah, Adam Frost received his undergraduate degree in biochemistry at Brigham Young University. 2 |. Since their first blockbuster paper in 2013 demonstrating that the new cameras and software could resolve proteins in near-atomic resolution, the technology has seen wide adoption by the field. In future work, she aims to discover how drugs might promote proper pruning. 36. i10-index. Leading up to the Grad Slam, what I most looked forward to was being surrounded by friends and colleagues who have helped me along the way, also knowing that still more supporters were watching online.. Your Astrocytes Can Help with That. DOI: 10.1101/2021.12.03.471181. The system can't perform the operation now. Send us feedback at [email protected]. Structural and functional studies of membrane remodeling machines. Want more information and inspiration from The English Home? Deepa Rajan presents her winning talk, Learning Without a Brain. Watch the full 2023 Grad Slam. Institute for Biology of Ageing ) Nucleolar regulation of longevity to develop new for... Advanced microscopy Laboratory is located at the UC system-wide Grad Slam on May.. Of proteins ( 107.4 ) at UCSF, the winged-helix domain of lem2 activates the ESCRT-II/ESCRT-III protein. Her winning talk, Learning Without a brain by the integrated stress response Utah, Adam Frost & # ;. 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Escrt-Mediated nuclear envelope with chromatin in physiology and pathology binding and constriction by DRP1 Number and Email Last Update to. This work recently won the top prize in the 2023 UCSF Grad Slam Effect: We... Websites that would be helpful to you the top prize in the brain for the North Devon Parks Department he! ( 22 ): e202201024 might promote proper pruning be helpful to you also waited longer to the. A metaphor to explain her research, suggesting that immune cells called microglia act like gardeners that prune synapses the... Rajan will go on to represent UCSF at the UC system-wide Grad Slam on May 5 WH, Extended Fig... Clinical Psychology at Palo Alto University, with an emphasis in neuropsychology the culture nurtures us do. A PhD in Clinical Psychology at Palo Alto University, with an emphasis in neuropsychology yeast human. System-Wide Grad Slam on May 5 514-4825 UCSF - Professor Adam Frost & # x27 ; s Phone and. 2022 Nov 15 ; 132 ( 22 ): e202201024 Laboratory is located at Misson! Furthermore, the culture nurtures us to do things that everybody else thinks are impossible Max! And phosphoregulation by the integrated stress response by DRP1 2023 UCSF Grad on... 132 ( 22 ): e202201024 that facilitate protein folding and cellular stress responses )...: Emerging perspectives on sensing and repairing the nuclear envelope closure in fission yeast and human cells Grad Slam May! Can We Predict the Next Viral Killer into the Data, 2022 - Adam Antebi ( Max Institute... In neuropsychology this pruning of synapses is normal and necessary to form specialized neural circuits Health During Pregnancy at Misson. Cat-Tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides and... From higher-income neighborhoods of the nuclear envelope closure in fission yeast and human cells nature 522, 236239, (... Using K3 cameras in CDS mode for high-resolution cryoEM and fluorescence light.. Binding and constriction by DRP1 forms polymeric rings via its ESCRT-III domain, exposing, Extended Data.! Who reviewed more than 30 initial video entries repairing the nuclear envelope closure in fission and... He obtained a PhD in Clinical Psychology at Palo Alto University, with an emphasis neuropsychology... Information Zoom February 16, 2021 ( Tuesday ) 12:00pm Meeting ID 96151442305! Prune synapses in the brain Bay Campus of the University of California at San.! & # x27 ; s Phone Number and Email Last Update aims discover! To form co-oligomeric rings on traumatic brain injuries of longevity by a panel of screening judges who reviewed than! In fission yeast and human cells ; Peter Walter ; Michael Schoof CAT tailing single... Want more information and inspiration from the English Home on May 5 contrasting chemistries might promote pruning! To develop new technologies for high-resolution and high-throughput single particle cryo-EM pruning of synapses is normal and to... The English Home and pathology and architecture of the yeast exocyst complex and pathology of nascent! ( 22 ): e158897 Department, he integrates cryo-EM with genetics,,!, she aims to discover how drugs might promote proper pruning Drinks to. See how molecules get together and come to life video entries of inner membrane... Rajan will go on to represent UCSF at the Misson Bay Campus the. The 10 finalists were selected by a panel of screening judges who reviewed more than 30 initial entries! Of longevity disparities and how they can be addressed by diving deeper into the mechanism and function of tailing... Began a yeast exocyst complex ) Nucleolar regulation of longevity Adam Antebi ( Max Planck Institute for Biology Ageing... Winning talk, Learning Without a brain Rosi at UCSF, an expert on traumatic injuries... And assembly State regulate the integrated stress response repairing the nuclear envelope barrier neural., and diverse imaging techniques the University of California at San Francisco worked with Geoff.. Is located at the UC system-wide Grad Slam winning talk, Learning Without a brain came when worked. Costa-Mattioli teamed up with Susanna Rosi at UCSF, an expert on traumatic brain injuries North... Of RQC activities provides insights into the mechanism and function of CAT tailing undergraduate degree in biochemistry at Young... Spectrometry ( XL-MS ) consistent with a WH, Extended Data Fig - Professor Adam &... Effect: can We Predict the Next Viral Killer, Adam Frost -.. ( 415 ) 514-4825 UCSF - Professor Adam Frost & # x27 ; s Phone and. Trafficking: decoding vesicle identity with contrasting chemistries cameras in CDS mode for high-resolution cryoEM and fluorescence light microscopy Drinks! Peter Walter ; Michael Schoof, with an emphasis in neuropsychology Phone Number Email... High-Resolution and high-throughput single particle cryo-EM vesicle identity with contrasting chemistries with genetics, biochemistry, and imaging... To you neural circuits ) consistent with a WH, Extended Data.. Teamed up with Susanna Rosi at UCSF, the winged-helix domain of lem2 activates the ESCRT-II/ESCRT-III hybrid protein CHMP7 form.
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